Antigen-Adjuvant Composition


1,189,340. Antigen adjuvant compositions. AMERICAN CYANAMID CO. 13 Sept., 1967 No. 41833/67. Heading A5B. Adjuvant compositions comprise a water-inoil or a water-in-oil-in-water emulsion, the oil being a physiologically acceptable oil, at least 0.15% w/v of a hydrated salt of a physiologically acceptable divalent or polyvalent metal and a physiologically acceptable fatty acid having from 12 to 24 carbon atoms, and an antigenic material present in a sufficient amount for producing immunologically satisfactory anti body formation. The metal may be Al, Fe, Mg, Ce, Zn, La or Bi and the fatty acid may be palmitic, stearic, lauric, myristic, arachidic, behenic, lignoceric, ricinoleic, oleic, erucic or linoleic acid, the preferred salt being aluminium monostearate. The oil may be peanut, safflower, soy bean, cotton seed, corn, chaulmoogra, olive, sesame, coconut or light mineral oil. The composition may also comprise an emulsifying agent of the type which favours formation of oil-in-water emulsions e.g. polyoxyethylene sorbitan monooleate. The antigenic materials may be derived from viruses e.g. influenza and foot and mouth antigens; mickettsia; bacteria e.g. tetanus toxoid; polysaccharides e.g. pneumococci, tumours allergic materials e.g. pollens, dust, danders and extracts thereof such as rag weed, house dust, pollen and grass extracts; and poisons or venoms of bees, wasps, poisonous snakes, scorpions and Lactrodectus mactans.




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Cited By (8)

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    DE-3241113-A1May 10, 1984Bayer AgVakzinen mit zuschlagstoffen
    EP-0108316-A2May 16, 1984Bayer AgVaccines with additives
    EP-0108316-A3October 08, 1986Bayer AgVaccines with additives
    EP-0363835-A1April 18, 1990BEHRINGWERKE AktiengesellschaftVerwendung von Zink- oder Eisenhydroxid zur Adjuvierung von Antigenlösungen und auf diese Weise adjuvierte Antigenlösungen
    FR-2533827-A1April 06, 1984AnvarComposition possedant des proprietes immunoregulatrices, notamment d'adjuvants immunologiques non specifiques, a base de muramylpeptide et d'un derive d'aluminium
    FR-2577139-A1August 14, 1986Israel Mini AgricultComposition de vaccin et mode de sa preparation
    US-4698221-AOctober 06, 1987Bayer AktiengesellschaftVaccines containing fat soluble vitamins, zinc compounds and selenium compounds
    US-5252327-AOctober 12, 1993Behringwerke AktiengesellschaftSolutions containing antigen and zinc hydroxide or iron hydroxide as an adjuvant and processes for preparing such solutions